The estrogen receptors were examined by immunohistochemical analysis (IHA) on 21 cases of resected stomach cancer.
@ES The results Were:
@EN 1. Seven out of 21 cases showed positive reaction; Grade9G) 3 staining in 1 case, G2 in 3 and G1 in 3 cases.
2. Among positives, 1 G2 had poorly differentiated tumor (PD), 2 G2 had moderatly differentiated (MD) and 1 G2 had PD, and 3 G2 had all MD.
3. Among all 21 cases, there were 2 well differentiated tumors that were ER negative; 5 were positive among 1 MD cases; 2 were positive among 8 PD cases.
4. Five out of the 6 evaluable ER positives and 11 out of the 13 evaluable negatives showed NED(no evidence of disease) or responses to chemotherapy.
5. Two out of 7 patients at or older than 60 year old and 1 out of 3 patients below 40 year old were ER positve.
6. IHA was good to discern ER positive area in tumor tissue, but needed more objective parameter to assess the degree of ER positivity.
7. Concommitant assay of the other sex hormone receptors like progesterone or androgen receptor as well as further trial of ER assay, and trial with tamoxifen and/or progesterone seemed to be necessary as further investigations for more accurate
assessment of the roles of the sex hormones in the basis of the treatment of stomach cancer.
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